NEW SCIENTIFIC STUDY: Introduction to Cerule’s unique, proprietary blend of Collagen and Cyactiv, CollagenActiv

Summary report on in vitro tests carried out on Aphanizomenon flos-aquae (AFA) samples for cosmetic use.

In vitro efficacy study evaluation of repairing effect of a Aphanizomenon flos-aquae (AFA) on cell culture.

Mobilization of human CD34+CD133+ and CD34+CD133 stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae—B related to modulation of CXCR4 expression by an L-selectin ligand. Cardiovascular Revascularization Medicine 8 (2007) 189–202

Kushak R, Drapeau C, Van Cott E (Winter HH 2000) Favorable effects of blue-green algae Aphanizomenon flos-aquae on rat plasma lipids. JANA vol. 2 (3): 59-65

Drapeau C, Aphanizomenon flos-aquae and the nervous system, attention deficit disorder, depression and mood elevation.

Hart A, Zaske L, Patterson K, Drapeau C, Jensen G (2007) Natural killer cell activation and modulation of chemokine receptor profile in vitro by an extract from the cyanophyta Aphanizomenon flos-aquae. Journal of Medicinal Food, 10(3): 435-441

Jensen G, Carter S, Redman K, Benson K, Ehmann A, Guthrie J, Turner J, Drapeau C (2009) Cognitive enhancement and immune modulating properties of an antioxidant-rich microalgae extract - AFAninPlus. SupplySide West 2009 Poster Session

Pugh N, Ross S, ElSohly H, ElSohly M, Pasco D (2001) Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, Aphanizomenon flos-aquae and Chlorella pyrenoidosa. Planta Medica Journal of Medicinal Plant and Natural Product Research, 67, 737 742

Schaeffer D, Krylove V (2000) Anti-HIV activity of extracts and compounds from algae and cyanobacteria. Ecotoxicology and Environmental Safety, 45, 208-227

Lahitova N, Doupovcova M, Zvonar J, Chandoga J, Hocman G (1994) Antimutagenic properties of fresh-water blue-green algae. Folia Microbiol, 39(4), 301-307

Romay C, Armesto J, Remirez D, Gonzalez R, Ledon N, Garcia I (1998) Antioxidant and Anti-inflammatory Properties of C-phycocyanin from Blue-green Algae. Inflammation Research, 47: 36-41

Gonzalez R, Rodriguez S, Romay C, Ancheta O, Gonzalez A, Armesto J, Remirez D, Merino N (1999) Anti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats. Pharmaccological Research, 39(1):55-9

Romay C, Ledon N, Gonzalez R (1998) Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation. Inflammation Research, 47(8):334-8

Reddy C, Bhat VB Kiranmai G, Reddy M, Reddanna P, Madyastha K (2000) Inhibition of cyclooxygenase-2 by C-phycocyanin, a biliprotein from Spirulina platensis. Biochemical and Biophysical Research Communications, 277(3):599-603

Remirez D, Gonzáles A, Merino N, González R, Ancheta O, Romay C, Rodrigues S (1999) Effect of phycocyanin in zymosan-induced arthritis in mice-phycocyanin as an antiarthritic compound. Drug Development Research, 48:70-75

Rimbau V, Camins A, Romay C, Gonzáles R, Pallas M (1999) Protective effects of C-phycocyanin against kainic acid-induced neuronal damage in rat hippocampus. Neuroscience Letters, Dec 3: 276:75-78

Rimbau V, Camins A, Pubill D, Sureda F, Romay C, González R, Jimenéz A, Escubedo E, Camarasa J, Pallás M (2001) C-Phycocyanin protects cerebellar granule cells from low potassium/serum deprivation-induced apoptosis. Naunyn-Schmiedeberg’s Archives of Pharmacology, 364:96-104.

Romay C, Ledón N, González R (2000) Effects of phycocyanin extract on prostaglandin E2 levels in mouse ear inflammation test. Arzneimittel.-Forschung./Drug Research, 50(II), Nr12, 1106-1109

Bhat, V, Gaikwad N, Madyastha K (1998) Hepatoprotective effect of C-phycocyanin: protection for carbon tetrachloride and R-(+)-pulegone-mediated hepatotoxicty in rats. Biochemical and Biophysical Research Communications, 249(2):428-31

Bhat V, Madaystha K (2000) C-Phycocyanin: A potent peroxyl radical scavenger in vivo and in vitro. Biochemical and Biophysical Research Communications, 275, 20-25

Carter SG, Redman KA, Benson KF, Ehmann A, Guthrie J, Norris L, Turner J, Jensen, GS. Analegisic and anti-inflammatory properties of a novel phycocyanin-rich microalgae extract, CyaninPlusTM. SSW09 poster session.

Romay C, González R, Ledón N, Remirez D, and Rimbau V (2003) C-Phycocyanin: a biliprotein with antioxidant, anti-inflammatory and neuroprotective effects. Current Protein and Peptide Science, 4, 000-000 1

Khan M, Vradharaj S, Ganesan L, Shobha J, Naidu M, Parinadi N, Tridandapani S, Kutala V, Kuppusamy P (2006) C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling. American Journal of Physiology Heart and Circulatory Physiology, May 290 (5) H2136-45

Benedetti S, Benvenuti F, Pagliarani S, Francogli S, Scoglio S, Canestrari F (2004) Antioxidant properties of a novel phycocyanin extract from the blue-green alga Aphanizomenon flos-aquae. Life Sciences, Sep 24;75(19):2353-62

Hsiao G, Chou P, Shen M, Chou D, Lin C, Sheu J (2005) C-phycocyanin, a very potent and novel platelet aggression inhibitor from Spirulina platensis. Journal of Agricultural Food Chemicals, Oct 5;53 (20):7734-40

Jensen GS, Attridge VL, Carter SG, Guthrie J, Ehmann A, Benson, KF (2016) Consumption of an aqueous cyanophyta extract derived from Arthrospira platensis is associated with reduction of chronic pain: results from two human clinical pilot studies. Nutrition and Dietary Supplements 2016:8 65–70

Sabelli H, Fink P, Fawcett J, Tom C (1996) Sustained antidepressant effect of PEA replacement. Journal of Neuropsychiatry and Clinical Neurosciences, 8(2):168-71

Szavo A, Billett, E, Turner J (2001) Phenylethylamine, a possible link to the antidepressant effects of exercise? Journal of Sports Medicine, 35, 342-343